Karel Pacak Selected Research

Mannans

11/2021	Mannan-BAM, TLR ligands, and anti-CD40 immunotherapy in established murine pancreatic adenocarcinoma: understanding therapeutic potentials and limitations.
8/2021	Identification of Immune Cell Infiltration in Murine Pheochromocytoma during Combined Mannan-BAM, TLR Ligand, and Anti-CD40 Antibody-Based Immunotherapy.
3/2021	Mannan-BAM, TLR Ligands, Anti-CD40 Antibody (MBTA) Vaccine Immunotherapy: A Review of Current Evidence and Applications in Glioblastoma.
9/2020	Induction of Immune Response Against Metastatic Tumors via Vaccination of Mannan-BAM, TLR Ligands and Anti-CD40 Antibody (MBTA).
8/2019	Coley's immunotherapy revived: Innate immunity as a link in priming cancer cells for an attack by adaptive immunity.
5/2019	The Significant Reduction or Complete Eradication of Subcutaneous and Metastatic Lesions in a Pheochromocytoma Mouse Model after Immunotherapy Using Mannan-BAM, TLR Ligands, and Anti-CD40.

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Karel Pacak Research Topics

Disease

202	Neoplasms (Cancer) 11/2022 - 01/2002
176	Pheochromocytoma 01/2022 - 03/2002
151	Paraganglioma (Paragangliomas) 01/2022 - 03/2002
39	Neoplasm Metastasis (Metastasis) 01/2022 - 08/2006
26	Hypoxia (Hypoxemia) 01/2021 - 09/2012
25	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2021 - 07/2003
17	Hypertension (High Blood Pressure) 02/2022 - 09/2002
14	Multiple Endocrine Neoplasia Type 2a (MEN 2) 06/2017 - 06/2005
12	von Hippel-Lindau Disease (von Hippel Lindau Disease) 12/2021 - 02/2005
9	Carcinogenesis 01/2019 - 06/2005
8	Obesity 01/2019 - 11/2006
8	Neurofibromatosis 1 (Neurofibromatosis Type I) 06/2017 - 06/2005
7	Polycythemia (Erythrocytosis) 05/2019 - 03/2013
5	Tachycardia (Tachyarrhythmias) 01/2020 - 03/2008
5	Cardiomyopathies (Cardiomyopathy) 07/2019 - 06/2011
5	Disease Progression 06/2019 - 01/2013
5	Heart Failure 01/2014 - 11/2006
4	Hemangioblastoma 12/2021 - 01/2017
4	Renal Cell Carcinoma (Grawitz Tumor) 03/2021 - 03/2012
4	Hyperplasia 07/2019 - 05/2006
4	Cushing Syndrome 08/2018 - 05/2004
4	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 04/2016 - 01/2008
3	Carcinoma (Carcinomatosis) 11/2021 - 09/2007
3	Carotid Body Tumor 01/2021 - 07/2003
3	Hyperthyroidism 01/2020 - 12/2003
3	Hypotension (Low Blood Pressure) 01/2020 - 07/2003
3	Headache (Headaches) 01/2019 - 01/2004
3	Somatostatinoma 11/2017 - 03/2013

Drug/Important Bio-Agent (IBA)

89	CatecholaminesIBA 02/2022 - 03/2002
76	Succinate Dehydrogenase (Fumarate Reductase)IBA 11/2022 - 06/2005
29	Norepinephrine (Noradrenaline)FDA LinkGeneric 12/2020 - 02/2002
23	Proteins (Proteins, Gene)FDA Link 11/2022 - 10/2005
21	Biomarkers (Surrogate Marker)IBA 10/2021 - 12/2002
19	EnzymesIBA 11/2022 - 08/2006
19	Epinephrine (Adrenaline)FDA LinkGeneric 12/2020 - 06/2003
17	MetanephrineIBA 12/2019 - 05/2002
16	Radioisotopes (Radionuclides)IBA 01/2022 - 05/2004
16	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2021 - 08/2004
15	NormetanephrineIBA 01/2022 - 05/2002
15	RadiopharmaceuticalsIBA 01/2021 - 08/2004
13	Dopamine (Intropin)FDA LinkGeneric 04/2019 - 07/2003
12	fluorodopa F 18IBA 03/2020 - 10/2007
11	Succinic Acid (Succinate)IBA 11/2022 - 01/2013
11	3-methoxytyramine (methoxytyramine)IBA 01/2022 - 04/2005
11	gallium Ga 68 dotatateIBA 01/2022 - 02/2016
11	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 01/2021 - 08/2008
11	3-Iodobenzylguanidine (Iobenguane)IBA 01/2019 - 09/2003
10	Hormones (Hormone)IBA 01/2021 - 08/2003
9	Somatostatin Receptors (Somatostatin Receptor)IBA 01/2021 - 03/2004
8	LigandsIBA 11/2021 - 03/2005
8	Erythropoietin FDA Link 01/2021 - 06/2005
7	Adrenergic Receptors (Adrenergic Receptor)IBA 02/2022 - 01/2010
7	Pharmaceutical PreparationsIBA 01/2022 - 02/2011
7	Adrenergic Agents (Adrenergic Drugs)IBA 01/2022 - 06/2005
7	Myc associated factor XIBA 01/2018 - 05/2012
7	Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)IBA 11/2012 - 02/2003
7	Messenger RNA (mRNA)IBA 11/2012 - 10/2005
6	Phosphotransferases (Kinase)IBA 01/2022 - 06/2013
6	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2021 - 08/2014
6	MannansIBA 11/2021 - 05/2019
6	Peptide Receptors (Peptide Receptor)IBA 01/2021 - 12/2016
6	Adenosine Triphosphate (ATP)IBA 01/2019 - 01/2013
6	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 09/2002
5	Peptides (Polypeptides)IBA 01/2021 - 05/2007
5	lutetium Lu 177 dotatateIBA 01/2021 - 06/2019
5	Carboxypeptidase H (Carboxypeptidase E)IBA 01/2020 - 11/2010
5	Tricarboxylic AcidsIBA 01/2018 - 08/2015
5	Glucose (Dextrose)FDA LinkGeneric 11/2017 - 04/2012
4	4-carboxyphenylglyoxalIBA 01/2022 - 01/2020
4	Retinaldehyde (Retinal)IBA 12/2021 - 11/2017
4	Toll-Like Receptors (Toll-Like Receptor)IBA 11/2021 - 05/2019
4	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2021 - 01/2010
4	IronIBA 01/2021 - 03/2011
4	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2021 - 06/2013
4	Oxygen (Dioxygen)IBA 01/2020 - 03/2013
4	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 04/2019 - 12/2008
4	Fumarate Hydratase (Fumarase)IBA 01/2019 - 03/2016
4	FumaratesIBA 01/2019 - 01/2014
4	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2018 - 01/2010
4	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 06/2017 - 02/2016
4	ParaffinIBA 01/2017 - 03/2002
4	Biological ProductsIBA 06/2016 - 01/2009
4	Transcription Factors (Transcription Factor)IBA 12/2015 - 08/2006
4	Dihydroxyphenylalanine (Dopa)IBA 02/2012 - 08/2004
4	Adrenocorticotropic Hormone (ACTH)FDA Link 08/2005 - 03/2004
3	Everolimus FDA Link 01/2022 - 05/2015
3	Octreotide (Sandostatin)FDA LinkGeneric 01/2021 - 01/2017
3	Chromogranin AIBA 08/2018 - 04/2014
3	Histone Deacetylase InhibitorsIBA 08/2017 - 02/2011
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 08/2017 - 01/2013
3	Hypoxia-Inducible Factor 1IBA 08/2017 - 11/2015
3	SteroidsIBA 06/2017 - 07/2010
3	Glucagon (Glukagon)FDA Link 05/2017 - 11/2008
3	Formaldehyde (Formol)FDA Link 01/2017 - 03/2002

Therapy/Procedure

50	Therapeutics 01/2022 - 09/2002
11	Precision Medicine 10/2021 - 11/2016
8	Adrenalectomy 01/2020 - 02/2003
8	Drug Therapy (Chemotherapy) 01/2019 - 08/2008
6	Immunotherapy 11/2021 - 05/2019
4	Radiotherapy 01/2019 - 12/2013